文献阅读02-2022-12-15

题目：recent advances in RNA structurome

摘要：

RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel models of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-RNA genome. we also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport localization, and mRNA translation-across viruses, bacteria, animals, and plants. we review many versatile RNA structural elements in the context of different physiological and pathological processes (cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel methods of RNA structures and functions for innovative applications.   

分析：

第一点：概括性语句，RNA结构对RNA功能和RNA调控的重要性

第二点：最近的RNA结构检测方法和RNA功能的模型

第三点：这篇综述准备讲的内容, 其实就是与第二点相呼应

3.1：概述，检测RNA结构的方法

3.2：概述，RNA结构的功能

第四点：展望：对未来RNA结构检测方法的展望