Unsupervised Discovery of Drug Side-Effects from Heterogeneous Data Sources

Feng long Ma et al.

Related Dataset

• Side effect claims: Healthboards, FDA/FEARS

1. Methods of discovering ADEs

Mehods	Description	Pros	Cons
Threshold	Potential ADEs would be recognized once if the bumber of its reports exceeds the threshold	Simplest	Fail to consider the reporters' reliabilty
Truth Discovery	Infer the ture information along with learning users' reliability degrees. 2 fundamental questions: single/multiple truth discovery	Tend to discover truth with higher quality

2. Definition of the ADE discovery problem

(1) Single object: drugs
(2) Multiple claims: users report multiple side-effects
(3) Reporters' quality: platform + user. For user quality, consider both pisitive claims and negative claims, final quality= Quality(users in positive claims) - Quality(users in negative claims)